Hemophilia


Description:
Any of several X-linked genetic disorders symptomatic chiefly in males in which excessive bleeding occurs owing to the absence or abnormality of a clotting factor in the blood.


Inheritance:
Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with those conditions are located on the X chromosome which is one of the two sex chromosomes. In males, one altered copy of the gene in each cell is sufficient to cause the condition. In female, a mutation would have to occur in both copies of the genes to cause disorder.



Symptoms:
A couple symptoms are easy bruising, frequent nosebleeds, and blood in urine. Usually you bleed after going to get dental work. Prolonged bleeding after the male child is circumcised.


Daily Life:

Diagnosis:
The majority of patients with hemophilia have a known family history of the condition. However, about one-third of cases occur in the absence of a known family. Most of these case, without a family history arise due to a spontaneous mutation in the affected gene. Other cases may be due to the gene being passed through a long like of female caries.

Treatment:
The main treatment for hemophilia is called replacement therapy. Concentrates of clotting factor are slowly dipped in or injected into a vein. These infusions help replace the clotting factor that’s missing or lost.

Research:
Treatment for hemophilia begins with seeking medical care from your health care provider. To determine whether you have hemophilia, your health care provider will likely draw blood samples for laboratory testing.



Additional Facts:
About 1 in every 5,000-10,000 is born with hemophilia. Mostly boys have and get hemophilia. Hemophilia-A is the type cause by lack of clotting factor 8. Hemophilia-B is caused my lack of clotting factor 9.






Punnett Square:

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Pedigree Chart:
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Pictures

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Males with Hemophilia




Resources:

For more info go to:
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001564/ http://ghr.nlm.nih.gov/condition/hemophilia