Description:
Hemophilia is an inherited disorder and the disease is x-linked. Hemophilia is when you can’t form an effective clot, which then causes prolonged bleeding. This won’t make the person bleed faster, just longer than usual. The disease is in mostly males. Also, there are two types of hemophilia, Hemophilia A and Hemophilia B.


Inheritance:
Hemophilia A is from deficiency or abnormality of factor VIII and Hemophilia B is from deficiency or abnormality of factor IX. These are both sex-linked recessive disorder as genes responsible for factor VIII and IX is on the X chromosome. The females are usually carriers and pass to their offspring on X chromosome. The female carries may be symptomatic since their lower than normal clotting factor levels.


Symptoms:
The symptoms for hemophilia:
· People bleed longer with hemophilia because blood doesn’t cut off well.
· A person with severe hemophilia can bleed to death, without treatment.
· The internal bleeding in the joints can lead to painful arthritis, with treatment.


Daily Life:








Diagnosis:
They usually diagnose hemophilia through factor assay. Before hemophilia is diagnosed, a doctor will have to perform several blood tests so they make sure it isn’t other disorders that share symptoms. The last test will determine if they have hemophilia and which type (A or B). Also, it determines how well the factor performs on the person. The way they take the blood tests is by switching the patient’s blood with normal plasma. This will determine and show the difference between the patients and normal plasma.


Treatment:
The two different kinds of hemophilia have different ways to be treated. For Hemophilia A they use a treatment called Xyntha. Xyntha uses a state-of-thee-art purification process that is fully free of any added human and animal material. Xyntha is a needle you inject for therapy of controlled bleeding. For Hemophilia B they use Benefix. This is an injectable medicine, which is supposed to help control and prevent bleeding. These can not treat the different hemophilia’s.




Research:
There’s not too much research done so far on hemophilia. In 1999 gene therapy clinic trials began research. It tried to cure hemophilia and in vitro fertilization may allow selection and implantation of embruos that lack the hemophilia gene. They are still considered experiments, nothing is final.

Additional Facts:
There are some additional facts to hemophilia. Approximately 1 in 5,000 live male births will get hemophilia. You can detect a carrier with DNA tests. Once a person gets diagnosed in your family, other family members can learn if they carry the mutation.


Punnett Square:




Drew_R_punnent_sguare.PNG



Pedigree Chart:


Drew_R_pedigree_chart.PNG


Pictures:
needle.jpg
needle for the injections they get for treatment
red_blood_cells.jpg
red blood cells
back_of_kness.jpg
bruises from hemophilia





Resources:

http://www.WebMD.com/a-to-z-guides/understanding-hen
http://www.pediatricionall.com/fordoctor/diseasesandcor
http://.www.ygyh.org/hemo/whatisit.htm