Description:
Marfan Syndrome is a disease that affects the bodies tissue, heart, eyes, and bones. Marfan Syndrome also affects the child’s weight, the child would become very thin, but they will have a tall and boney structure. This disease also affects the length of a persons arm and leg even your hands

Inheritance:
Marfan syndrome is a disorder of the connective tissue in the body; the tissue that strengthens the body’s structures. Disorders of the connective tissue affect the skeletal system, cardiovascular system, eyes and skin. A person with Marfan syndrome is inherited which means it is passed down through families. If the father had the disease there is a fifty percent chance that he may pass it down to his offspring. None could be carriers of the disease. The disease is only passed on if one of the parents has it. If none have it then the children won’t be affected. This disease is autosomal dominant. It can only be passed on if one of the parents has the disease.



Symptoms:
Marfan syndrome is a heritable condition that affects the connective tissue. The primary purpose of the connective tissue is to hold the body together and provide a framework throughout the body. The symptoms of this disease are the following:
· Flat feet
· Funnel chest
· Coloborna of iris
· Crowded teeth
· Hypertonia
· Learning disability
· Movement of the eye lens
· Near sightedness
· Scoliosis
· Small lower jaw
· Thin narrow face


Daily Life:
Your voki will be inserted here to explain the day in the life of a person with this disorder(centered)



Diagnosis:
The doctor will preform a physical exam. There may be hypermobile joints and signs of:
· Aneurysm
· Collapsed lung
· Heart valve problems

A heart exam may show:
· Defects of the lens or cornea
· Retinal detachment
· Vision problems
· Echocardiogram
· Flbrllin-1 mutation testing (in some people)


Treatment:
Vision problems are treated as soon as possible. Check your spinal cord for scoliosis especially during adolescence. Some doctors give medicine to slow the heart rate may help prevent stress on the aorta. Also people with Marfan syndrome should take antibiotics before dental procedures to prevent endocarditis. Avoid participating in competitive athletics and contact sports to avoid injuring the heart. Some people may need surgical replacement of the aortic root and valve.


Research:
There is a recent study being conducted. People can volunteer to practice in Marfan syndrome study. There is no known cure yet for Marfan syndrome. Doctors can treat about all of Marfan syndromes symptoms.

Additional Facts:
Marfan syndrome is named after Antoine Marfan. The French doctor who discovered the disorder in 1896. A few years ago no one lived past the age of forty if they had Marfan syndrome. Marfan syndrome is a defect in the Flbrllin-1, a special type of protein that’s found in the connective tissue. Marfan happens to about 1 in every 5,000 people. Marfan syndrome runs through both guys and girls of all ethnic backgrounds. When you have Marfan syndrome you will need to see four different doctors:
· Geneticist (gene doctor)
· Cardiologist (heart doctor)
· Ophthalmologist (eye doctor)
· Orthopedist (bone doctor)



Punnett Square:

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Pedigree Chart:


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mafan_sy.jpgbradford%2520cox.jpgmarfan-syndrome.jpg
Resources:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001455/
http://www.medicinenet.com/marfan_syndrome/article.htm
http://kidshealth.org/teen/diseases_conditions/genetic/marfan.html