Stickler+Syndrome+Ryan+K

Stickler Syndrome

**Description: ** Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. **Inheritance: **There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the //COL2A1 // , //COL9A1 // , //COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life:media type="custom" key="9718798" **
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: 'Times','serif'; font-size: 19px; line-height: 115%; text-align: center; text-decoration: none; vertical-align: auto;">Stickler Syndrome

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Description: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Inheritance: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL2A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL9A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">People with Stickler syndrome have to take daily medications. People with Stickler syndrome can help improve their hearing by wearing a hearing. Fortunately, Stickler syndrome DOES NOT affect life expectancy. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: 'Times','serif'; font-size: 19px; line-height: 115%; text-align: center; text-decoration: none; vertical-align: auto;">Stickler Syndrome
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Description: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Inheritance: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL2A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL9A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">People with Stickler syndrome have to take daily medications. People with Stickler syndrome can help improve their hearing by wearing a hearing. Fortunately, Stickler syndrome DOES NOT affect life expectancy. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: 'Times','serif'; font-size: 19px; line-height: 115%; text-align: center; text-decoration: none; vertical-align: auto;">Stickler Syndrome
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Description: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Inheritance: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL2A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL9A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">People with Stickler syndrome have to take daily medications. People with Stickler syndrome can help improve their hearing by wearing a hearing. Fortunately, Stickler syndrome DOES NOT affect life expectancy. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: 'Times','serif'; font-size: 19px; line-height: 115%; text-align: center; text-decoration: none; vertical-align: auto;">Stickler Syndrome
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Description: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Inheritance: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL2A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL9A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">People with Stickler syndrome have to take daily medications. People with Stickler syndrome can help improve their hearing by wearing a hearing. Fortunately, Stickler syndrome DOES NOT affect life expectancy. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: 'Times','serif'; font-size: 19px; line-height: 115%; text-align: center; text-decoration: none; vertical-align: auto;">Stickler Syndrome
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties

<span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Description: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome is a group of heredity conditions characterized by a distinctive facial appearance. It includes eye abnormalities, hearing loss, and joint problems. The symptoms can vary, however. Many people with Stickler Syndrome have severe nearsightedness because of a noticeable gel that fills the eyeballs. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Inheritance: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">There is a 50% chance that your offspring will have the disease. Stickler Syndrome has also been passed with a misprint in it from a parent. It is caused by mutations in the <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL2A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL9A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A1 // <span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">, and <span class="genesymbol" style="background-color: transparent; color: #000000; font-family: Times New Roman; font-size: 16px; text-decoration: none; vertical-align: auto;">//<span style="background-color: transparent; color: black; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">COL11A2 genes. These are genes involved in a formation of protein called collagen. // <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Symptoms: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Daily Life: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">People with Stickler syndrome have to take daily medications. People with Stickler syndrome can help improve their hearing by wearing a hearing. Fortunately, Stickler syndrome DOES NOT affect life expectancy. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Diagnosis: **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Stickler Syndrome can sometimes be diagnosed based on your child’s medical history. Sometimes you can diagnose it with even a simple physical exam. Additional test are sometimes needed to find the severity of the symptoms and help direct treatment decisions. X-rays can look at bone structures to see if there are any abnormalities. Eye exams can also see if gel is filling in your eyes. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Treatment: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: normal; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Arial','sans-serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">While there is no cure for Stickler syndrome, treatments can help control symptoms and prevent complications. In some cases, surgery may be needed to correct some of the physical abnormalities associated with Stickler syndrome. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Research: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">The NIAMS is conducting an in-depth history study on people who have Stickler syndrome and other diseases. Scientist are studying people who have stickler syndrome closely, and over a long period of time. They want to get a more complete picture of the disease. They hope to improve understanding of the genetic origins of the disease. <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Additional Facts: Stickler **<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Syndrome is often diagnosed during childhood. It is also called Heredity Arthro Ophthalmopathy. Stickler Syndrome has four sub divisions: <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 1 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 2 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 3 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; text-indent: -0.25in; vertical-align: auto;"><span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">- Stickler Syndrome 4 <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Punnett Square: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Pedigree Chart: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; line-height: 14.25pt; margin-bottom: 0pt; text-align: left; text-decoration: none; vertical-align: auto;">**<span style="background-color: transparent; color: black; font-family: 'Times','serif'; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;">Resources: ** <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #0000ff; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: underline; vertical-align: auto;">[] <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #0000ff; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: underline; vertical-align: auto;">[] <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #0000ff; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: underline; vertical-align: auto;">Pub Med Health
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Joint problems
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Eye abnormalities
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Hearing loss
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Nearsightedness
 * <span style="background-color: transparent; color: #000000; display: block; font-family: Times New Roman; font-size: 16px; text-align: left; text-decoration: none; vertical-align: auto;"><span style="background-color: transparent; color: #000000; font-family: 'Times','serif'; font-size: 16px; text-decoration: none; vertical-align: auto;">Breathing difficulties